Highly dynamic motion sequences during fully automatic component transfer in progressive presses can cause undesired vibrations of the transfer systems used. In order to avoid the negative influence of the vibrations on the workpieces to be transported, a process has been developed at the IFUM within the framework of a research project that enables an auto-adaptive minimization of the vibrations generated during transport. The development of the method has been realized via cross-software coupled simulation between a multi-body simulation model (MBS model) of the transfer device and a kinematics optimizer programmed in Matlab. With the software LMS Virtual.Lab, the design data of the transfer device was used to create a MBS model, which can be used to calculate the motions of the drive components as well as the resulting inertial forces. In Matlab, vibration-minimized kinematics are generated after each stroke, taking into account the vibrations of the transfer device calculated within the multibody simulation. To realize the necessary autoadaptive properties, the method is based on the evolutionary optimization algorithm CMA-ES. In order to generate vibration-minimized kinematics as well as to run the multibody simulation simultaneously, Matlab/Simulink and LMS Virtual.Lab were coupled via an existing software interface.